The intermediate source for nCoV-19 is still a puzzle which needs to be solved soon in order to find the viral transmission mode. Coronavirus from the family of the Coronaviridae consists of four genera which include alpha, beta, gamma and delta coronavirus (Ayittey et al. Coronaviruses are enveloped, positive single-stranded RNA viruses belong to theВ subfamily coronavirinae ofВ the Coronaviridae family. Till date no effective drug or vaccine is available for complete cure of COVID-19, so there is an urgent need to find the vaccine against the nCoV-19 (ul Qamar et al. The emerging respiratory syndrome (COVID-19) is associated with the novel coronavirus nCoV-19, and it was first discovered in December 2019 in the province Hubei, Wuhan city, China (Li et al. Here, the rationale of this review was also to provide an overview of the pathogenesis of the virus and summarize the updated potential vaccine candidates against SARS-CoV-2. Recent studies have revealed any attractive vaccine candidates as promising therapeutic agents based on different strategies of vaccines. mRNA-1273, ChAdOx1, Ad5-nCoV, INO-4800, LV-SMENP-DC and pathogen-specific aAPC are the most advanced and potential drug candidates against COVID-19. Multiple vaccine candidates are still in evaluation and exploratory stages on different clinical models with potential results on different animals and human models. Though efforts on development of SARS-CoV-2 vaccine have been started earlier as soon as the pandemic was emerged, till date no effective drug or vaccine has been validated with significant efficacy against the disease therefore, there is a dire need to design effective vaccine against SARS-CoV-2. Many antiviral drugs show efficacy but only in mild to moderate infection levels. The clinical symptoms of SARS-CoV-2 are very non-specific and include fever, sore throat, wheezing, rales, headache and rhinorrhoea with round-glass pulmonary opacifications shadowing in X-ray. SARS-CoV-2 uses human ACE2 receptor as a ligand to bind and transmit its genome just like the SARS-CoV. The article, therefore, provides a comprehensive study on the genomic, epidemiological, social, clinical and environmental aspects of SARS-CoV-2. The aim of this study is to discuss all the aspects related to recently discovered novel coronavirus. Till now 6,057,853 confirmed cases with 371,166 deaths have been reported from approximately 213 countries of the world. The WHO has declared an ongoing COVID-19 outbreak as a pandemic. COVID-19 has raised the concern ofВ the world since its emergence from China.

The novel coronavirus (nCoV-19) was firstly reported from Wuhan city inВ China.

The Happy Singers has also performed in charity events for Habitat for Humanity, Taiwan Earthquake Relief, Alzheimer Foundation, and the West Windsor Senior Center.In December 2019, WHO was informed with several unknown pneumonia cases and later it was found as highly contagious, transmittable and pathogenic viral infection. It has appeared in concert frequently in the West Windsor International Cultural Festival, and Plainsboro FounderвЂ™s Day and Cultural Day. It is devoted to community service and promoting Chinese culture via choral music. The Happy Singers was formed in 1993 with residents from the Greater Princeton area. In 2010, the chorus was invited to participate in the Globalization Concert of Temple University, performing with six other Chinese choruses in the famous вЂњYellow RiverвЂќ Cantata. It has participated in a concert at the Academy of Music in Philadelphia, celebrating the 125th anniversary of Philadelphia Chinatown. The Chinese Musical Voices was formed in 1988 by the residents of Southern New Jersey and the greater Delaware Valley region. The Chinese Musical Voices and Happy Singers have made joint appearances in Avery Fisher Hall of Lincoln Center in New York City. The Happy Singers and Chinese Musical Voices are both directed by their highly-acclaimed choral conductor, Wennie Nai-Yueh Niu.

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